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Overcoming Weight Regain After GLP-1s

 

By Yazen Assaf, MD

Have you regained weight after stopping GLP-1 medications like Ozempic or Wegovy? You’re not alone—studies show up to 70% of users discontinue within a year, regaining up to 75% of lost weight within months (JAMA, 2025). Unlike medications requiring weekly injections, bariatric surgery offers a "one-and-done" solution, delivering 25-30% body weight reduction sustained for 5+ years (ASMBS, 2025).

With a single procedure, bariatric weight loss surgery transforms your body’s metabolism, curbing hunger and boosting energy expenditure for long-term weight control. It tackles obesity-related issues like type 2 diabetes (up to 75% remission) and cardiovascular risk (45-56% reduction), offering a path to lasting health without the burden of lifelong injections  (JAMA, 2024). Our expert team provides tailored surgical solutions and robust team support to help you break the weight regain cycle.

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References

American Society for Metabolic and Bariatric Surgery. (2025, June 17). Head-to-head study shows bariatric surgery superior to GLP-1 drugs for weight loss. ASMBS. https://asmbs.org/news_releases/head-to-head-study-shows-bariatric-surgery-superior-to-glp-1-drugs-for-weight-loss/ 

Aminian, A., Aminian, E. S., Wilson, R. L., Nissen, S. E., Tu, C., & Brethauer, S. A. (2024). Reduced risk of cardiovascular diseases after bariatric surgery: A population-based cohort study of cardiovascular-kidney-metabolic health. Journal of the American Heart Association, 13(6), e038191. https://doi.org/10.1161/JAHA.124.038191 

Ghazi, L., DeFronzo, R. A., & Norton, L. (2025). Discontinuation and reinitiation of GLP-1 receptor agonists. JAMA Network Open, 8(1), e245789. https://doi.org/10.1001/jamanetworkopen.2024.5789

Hwang, J. J., Lee, S. Y., & Park, H. S. (2025). Trajectory of weight regain after cessation of GLP-1 receptor agonists. medRxiv. https://doi.org/10.1101/2025.06.09.25328726